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Innovación en reproducción asistida

Líneas de investigación

Infertilidad femenina.
Infertilidad masculina.
Mejora de los resultados en técnicas de reproducción asistida.

Foto grupo

Actividades del grupo

La reproducción humana y sus patologías están recibiendo una creciente atención como consecuencia de la frecuencia cada vez mayor de problemas reproductivos en las parejas y también por disponerse de técnicas cada vez más exitosas para el tratamiento de la esterilidad. Sin embargo, el éxito en la fecundación no llega a ser total y una buena parte de estos problemas sigue sin resolverse. Esto es debido a que muchos aspectos bioquímicos y fisiológicos de la reproducción humana son todavía desconocidos, lo cual hace imposible comprender la etiología de muchos casos de infertilidad.

Nuestro interés radica en profundizar en el estudio de los factores que afectan a la fertilidad humana y en la optimización de las Técnicas de Reproducción Asistida.

Infertilidad femenina - Problemática relacionada con la endometriosis, papel del supresor tumoral p27 en el desarrollo y función del ovario y en la fertilidad., implicación del sitema canabinoide y opioide en la maduración in vitro de los ovocitos humanos

Infertilidad masculina - Papel del estrés oxidativo seminal en la infertilidad masculina y el éxito reproductivo, eficacia de antioxidantes en el tratamiento del varón infértil y su capacidad para mejorar la funcionalidad espermática.

Mejora de los resultados en técnicas de reproducción asistida - Identificación de factores pronósticos de implantación embrionaria en el líquido endometrial mediante técnicas de proteómica; Implicación de las técnicas de reproducción asistida en la alteración de los patrones de impronta; Impacto de las técnicas de reproducción asistida en la salud del recién nacido; Biomarcadores ovocitarios y embrionarios como marcadores del éxito en reproducción asistida; Obesidad y reproducción asistida; Farmacoterapia de la reproducción asistida.

Coordinador/a del grupo



Miembros del grupo

  María Begoña Ruiz Larrea
 
  María Luisa Hernandez Frías
 
  Rosaura Navarro Lobato
 
  José Ignacio Ruiz Sanz
 
  Naiara Agirregoitia Marcos
 
  María Begoña Prieto Molano
 
 
  Jairo Pérez Sanz
 
  María Rosario Mendoza Hourtouat
 
 
  Beatriz Corcostegui Ormazabal
 
 
  Antonia Expósito Navarro
 
  Ekaitz Agirregoitia Marcos
 
  Aintzane Rabanal Nuñez
 
 
  María Victoria Aparicio Prieto
 
 
  María Díaz Núñez
 
 
  Jone Ibáñez Pérez
 
  Itziar Urizar Arenaza
 
  Nerea Subiran Ciudad
 
  Iraia Muñoa Hoyos
 
  Iker Malaina Celada
 
  Alberto Manuel Vendrell Bernabeu
 
 
  Ainara Bengoetxea de Cos
 
 
  Lucía Lourdes Lainz Palacio
 
 
  María Iglesias Calabria
 
 

Publicaciones del grupo

Schwarze J, Venetis C, Iniesta S, Falla E, Lukyanov V, de Agustin Calvo E, et al. Originator recombinant human follitropin alfa versus recombinant human follitropin alfa biosimilars in Spain: A cost-effectiveness analysis of assisted reproductive technology related to fresh embryo transfers. Best Pract Res Clin Obstet Gynaecol. 2022. DOI:10.1016/j.bpobgyn.2022.01.011.

Martinez L, Malaina I, Salcines Cuevas D, Teran Navarro H, Zeoli A, Alonso S, et al. First computational design using lambda-superstrings and in vivo validation of SARS-CoV-2 vaccine. Sci Rep. 2022; 12(1). DOI:10.1038/s41598-022-09615-w.

Matorras R, Navarro A, Ramos D, Malaina I, Irazusta J, Vendrell A, et al. Physical activity and sperm quality: influence in sperm donors. Reprod Biol Endocrinol. 2022; 20(1): 83-83. DOI:10.1186/s12958-022-00946-x.

Rodriguez Robledo V, Vendrell A, Garcia Cifuentes A, Villaseca Gonzalez N, Guiberteau Cabanillas C, Martinez LL, et al. Determination of atrazine and propazine metabolites deemed endocrine disruptors in human seminal plasma by LC-ESI-MS/MS. Chem Biol Technol Agric. 2022; 9(1). DOI:10.1186/s40538-022-00285-4.

Prieto B, Diaz Nunez M, Lainz L, Vendrell A, Rabanal A, Iglesias M, et al. Aspiration of excess follicles before intrauterine insemination in high response cycles. Reprod Med Biol. 2022; 21(1). DOI:10.1002/rmb2.12470.

Gianzo M, Urizar Arenaza I, Munoa Hoyos I, Labaka G, Larreategui Z, Garrido N, et al. Sperm aminopeptidase N identifies the potential for high-quality blastocysts and viable embryos in oocyte-donation cycles. Hum Reprod. 2022; 37(10): 2246-2254. DOI:10.1093/humrep/deac170.

Matorras R, Pijoan JI, Lainz L, Diaz Nunez M, Sainz H, Perez Fernandez S, et al. Polycystic ovarian syndrome and miscarriage in IVF: systematic revision of the literature and meta-analysis. Arch Gynecol Obstet. 2022. DOI:10.1007/s00404-022-06757-0.

Ibanez Perez J, Diaz Nunez M, Clos Garcia M, Lainz L, Iglesias M, Diez Zapirain M, et al. microRNA-based signatures obtained from endometrial fluid identify implantative endometrium. Hum Reprod. 2022; 37(10): 2375-2391. DOI:10.1093/humrep/deac184.

Gomez Pereira E, Burgos J, Mendoza R, Perez Ruiz I, Olaso F, Garcia D, et al. Endometriosis Increases the Risk of Placenta Previa in Both IVF Pregnancies and the General Obstetric Population. Reprod Sci. 2022. DOI:10.1007/s43032-022-01054-2.

Martin Inaraja M, Alonso S, Rodriguez C, Santos S, Iglesias M, Prieto B, et al. DNA-FISH analysis in testicular tissue cells of prepuberal patients with Klinefelter Syndrome. Hum Reprod. 2022; 37

Victoria Rodriguez Gallego M, Victoria Aparicio Prieto M, Leza Garcia A, Hernandez J, Antonio Arizaleta Uralde J, Casis Saenz L. Metabolism of renin-angiotensin and enkephalin in human follicular fluid: An experimental study. International Journal of Reproductive BioMedicine. 2022; 20(10): 851-860. DOI:10.18502/ijrm.v20i10.12269.

Matorras R, Ignacio Pijoan J, Perez Ruiz I, Lainz L, Malaina I, Borjaba S. Meta-analysis of the embryo freezing transfer interval. Reprod Med Biol. 2021; 20(2): 144-158. DOI:10.1002/rmb2.12363.

Urizar Arenaza I, Benedicto A, Perez Valle A, Osinalde N, Akimov V, Munoa Hoyos I et al. The multifunctional role of SPANX-A/D protein subfamily in the promotion of pro-tumoural processes in human melanoma. Sci Rep. 2021; 11(1): 3583-3583. DOI:10.1038/s41598-021-83169-1.

Navarro B, Gomez Gimenez B, Urizar Arenaza I, Ganzabal T, Martin S, Subiran N. Sperm nullisomy is not associated with routine semen parameters but it negatively impacts on ICSI outcomes. Andrologia. 2021; 53(6): 14026-14026. DOI:10.1111/and.14026.

Gianzo M, Urizar Arenaza I, Munoa Hoyos I, Larreategui Z, Garrido N, Irazusta J et al. (Pro)renin Receptor Is Present in Human Sperm and It Adversely Affects Sperm Fertility Ability. Int J Mol Sci. 2021; 22(6). DOI:10.3390/ijms22063215.

Munoa Hoyos I, Araolaza M, Urizar Arenaza I, Gianzo M, Irazusta J, Subiran N. Sex dependent alteration of epigenetic marks after chronic morphine treatment in mice organs. Food Chem Toxicol. 2021; 152: 112200-112200. DOI:10.1016/j.fct.2021.112200.

De la Fuente IM, Martinez L, Carrasco Pujante J, Fedetz M, Lopez JI, Malaina I. Self-Organization and Information Processing: From Basic Enzymatic Activities to Complex Adaptive Cellular Behavior. Front Genet. 2021; 12: 644615-644615. DOI:10.3389/fgene.2021.644615.

Canon Beltran K, Cajas YN, Perez Cerezales S, Leal CLV, Agirregoitia E, Gutierrez Adan A et al. Nobiletin enhances the development and quality of bovine embryos in vitro during two key periods of embryonic genome activation. Sci Rep. 2021; 11(1). DOI:10.1038/s41598-021-91158-7.

Matorras R, Valls R, Azkargorta M, Burgos J, Rabanal A, Elortza F et al. Proteomics based drug repositioning applied to improve in vitro fertilization implantation: an artificial intelligence model. Syst Biol Reprod Med. 2021; 67(4): 281-297. DOI:10.1080/19396368.2021.1928792.

Bregon Villahoz M, Moragues M, Arrieta Aguirre I, Azkargorta M, Lainz L, Diez Zapirain M et al. Antibacterial and Antifungal Activity of the Human Endometrial Fluid during the Natural Cycle. Infectious Diseases in Obstetrics and Gynecology. 2021; 2021: 8849664-8849664. DOI:10.1155/2021/8849664.

Viudez A, Crespo G, Dorronsoro MLG, Arozarena I, Marin Mendez JJ, Custodio A et al. Usefulness of an immunohistochemical score in advanced pancreatic neuroendocrine tumors treated with CAPTEM or everolimus. Pancreatology. 2021; 21(1): 215-223. DOI:10.1016/j.pan.2020.12.009.

Fan X, Moustakas I, Torrens Juaneda V, Lei Q, Hamer G, Louwe LA et al. Transcriptional progression during meiotic prophase I reveals sex-specific features and X chromosome dynamics in human fetal female germline. PLoS Genet. 2021; 17(9): 1009773-1009773. DOI:10.1371/journal.pgen.1009773.

Aparicio Prieto MV, Rodriguez Gallego MV, Valdivia Palacin A, Franco Iriarte Y, Hervas Barbara G, Echevarria Orella E et al. Local renin angiotensin system and sperm DNA fragmentation. Asian J Androl. 2021. DOI:10.4103/aja202150.

Perez Ruiz I, Ruiz Sanz J, Hernandez M, Navarro R, Ferrando M, Larreategui Z et al. Evidence of Paraoxonases 1, 2, and 3 Expression in Human Ovarian Granulosa Cells. Antioxidants (Basel). 2021; 10(10). DOI:10.3390/antiox10101504.

Carrasco Pujante J, Bringas C, Malaina I, Fedetz M, Martinez L, Perez Yarza G et al. Associative Conditioning Is a Robust Systemic Behavior in Unicellular Organisms: An Interspecies Comparison. Front Microbiol. 2021; 12. DOI:10.3389/fmicb.2021.707086.

Subiran N, Urizar Arenaza I, Munoa Hoyos I, Irazusta J, Larreategui Z, Garrido N et al. Sperm Aminopeptidase N as a predictive biomarker of blastocyst development and embryo viability. Hum Reprod. 2021; 36: 70-71

Suárez García I, Ruiz Algueró M, García Yubero C, Moreno C, Belza MJ, Estébanez M, et al. Physicians' opinions on generic antiretroviral drugs and single-tablet regimen de-simplification for the treatment of HIV infection: a multicentre survey in Spain. J Antimicrob Chemother. 2020; 75(2): 466-472. DOI:10.1093/jac/dkz439.

Azkargorta M, Bregón Villahoz M, Escobes I, Ibáñez Pérez J, Iloro I, Iglesias M, et al. In-depth proteomics and natural peptidomics analyses reveal antibacterial peptides in human endometrial fluid. J Proteomics. 2020; 216: 103652-103652. DOI:10.1016/j.jprot.2020.103652.

Valdivia A, Cortes L, Beitia M, Totorikaguena L, Agirregoitia N, Corcostegui B, et al. Role of Angiotensin-(1-7) via Mas receptor in human sperm motility and acrosome reaction. Reproduction. 2020; 159(3): 241-249. DOI:10.1530/REP-19-0274.

Matorras R, Martinez Arranz I, Arretxe E, Iruarrizaga Lejarreta M, Corral B, Ibañez Perez J, et al. The lipidome of endometrial fluid differs between implantative and non-implantative IVF cycles. J Assist Reprod Genet. 2020; 37(2): 385-394. DOI:10.1007/s10815-019-01670-z.

Matorras R, Exposito A, Ferrando M, Mendoza R, Larreategui Z, Laínz L, et al. Oocytes of women who are obese or overweight have lower levels of n-3 polyunsaturated fatty acids compared with oocytes of women with normal weight. Fertil Steril. 2020; 113(1): 53-61. DOI:10.1016/j.fertnstert.2019.08.059.

Prieto I, Rubio Alarcon C, Garcia Gomez R, Berdun R, Urgel T, Portero M, et al. Metabolic adaptations in spontaneously immortalized PGC-1 alpha knock-out mouse embryonic fibroblasts increase their oncogenic potential. Redox Biol. 2020; 29. DOI:10.1016/j.redox.2019.101396.

Urizar Arenaza I, Osinalde N, Akimov V, Puglia M, Muñoa Hoyos I, Gianzo M, et al. SPANX-A/D protein subfamily plays a key role in nuclear organisation, metabolism and flagellar motility of human spermatozoa. Sci Rep. 2020; 10(1): 5625-5625. DOI:10.1038/s41598-020-62389-x.

Matorras R, Zallo A, Hernandez Pailos R, Ferrando M, Quintana F, Remohi J, et al. Cervical pregnancy in assisted reproduction: an analysis of risk factors in 91,067 ongoing pregnancies. Reprod Biomed Online. 2020; 40(3): 355-361. DOI:10.1016/j.rbmo.2019.12.011.

Lekerika Royo N, Martinez Ruiz A, Arco Vazquez J, Gutierrez Rico RM, Prieto Molano L, Arana Arri E, et al. Transfusional optimization in liver transplant using viscoelastic test guided therapy. Rev Esp Anestesiol Reanim. 2020. DOI:10.1016/j.redar.2020.01.015.

Penas C, Apraiz A, Munoa I, Arroyo Berdugo Y, Rasero J, Ezkurra PA, et al. RKIP Regulates Differentiation-Related Features in Melanocytic Cells. Cancers (Basel). 2020; 12(6). DOI:10.3390/cancers12061451.

Uribe Etxebarria V, Garcia Gallastegui P, Perez Garrastachu M, Casado Andres M, Irastorza I, Unda F, et al. Wnt-3a Induces Epigenetic Remodeling in Human Dental Pulp Stem Cells. Cells. 2020; 9(3). DOI:10.3390/cells9030652.

Aja I, Ruiz Larrea MB, Courtois A, Krisa S, Richard T, Ruiz Sanz J. Screening of Natural Stilbene Oligomers from Vitis vinifera for Anticancer Activity on Human Hepatocellular Carcinoma Cells. Antioxidants (Basel). 2020; 9(6). DOI:10.3390/antiox9060469.

Iliuta F, Pijoan JI, Lainz L, Exposito A, Matorras R. Women's vitamin D levels and IVF results: a systematic review of the literature and meta-analysis, considering three categories of vitamin status (replete, insufficient and deficient). Hum Fertil. 2020; 25(2): 228-246. DOI:10.1080/14647273.2020.1807618.

Myriam M, Armendariz E, Herrera L, Rodriguez C, Roig N, Garcia Quevedo L, et al. Future stem cell therapies in fertility preservation of prepuberal children with cancer or genetic syndromes. Improvements in the characterization of human Spermatogonial Stem Cells. Hum Reprod. 2020; 35: 1505-1506

Perez JI, Diaz Nunez M, Lainz L, Diez Zapirain M, Iglesias M, Exposito A, et al. Endometrial fluid derived extracellular vesicles as low-invasive diagnostic biomarkers of implantative endometrium. Hum Reprod. 2020; 35: 306-306

Munoa Hoyos I, Halsall JA, Araolaza M, Ward C, Garcia I, Urizar Arenaza I, et al. Morphine leads to global genome changes in H3K27me3 levels via a Polycomb Repressive Complex 2 (PRC2) self-regulatory mechanism in mESCs. Clin Epigenetics. 2020; 12(1): 170-170. DOI:10.1186/s13148-020-00955-w.

Gianzo M, Subiran N. Regulation of Male Fertility by the Renin-Angiotensin System. Int J Mol Sci. 2020; 21(21). DOI:10.3390/ijms21217943.

Arenaza IU, Navarro B, Gomez Gimenez B, Odriozola A, Martin Gonzalez S, Munoa Hoyos I, et al. Proteomic characterization of spermatozoa from patients with idiopathic infertility. Hum Reprod. 2020; 35: 9-9

Subiran N, Munoa Hoyos I, Araola Lasa M, Urizar Arenaza I, Gianzo M, Irazusta J. Morphine treatment prevents the X chromosome inactivation and maintains a long-term repression by SMCHD1 epigenetic regulator. Hum Reprod. 2020; 35: 380-380

Urizar Arenaza I, Osinalde N, Akimov V, Puglia M, Munoa Hoyos I, Gomez Gimenez B, et al. Kappa- opioid receptor regulates human sperm functions via SPANX-A/D protein family. Reproductive Biology. 2020; 20(3): 300-306. DOI:10.1016/j.repbio.2020.07.003.

De la Fuente IM, Bringas C, Malaina I, Fedetz M, Carrasco Pujante J, Morales M, et al. Evidence of conditioned behavior in amoebae. Nat Commun. 2019; 10(1): 3690-3690. DOI:10.1038/s41467-019-11677-w.

Martinez L, Milanic M, Malaina I, Alvarez C, Perez M, de la Fuente IM. Weighted lambda superstrings applied to vaccine design. PLoS One. 2019; 14(2). DOI:10.1371/journal.pone.0211714.

Matorras R, Berreteaga L, Lainz L, Exposito A, Martinez L. Influence of Caesarean section-pregnancy interval on uterine rupture risk and IVF pregnancy rates: systematic review and mathematical modelling. Reprod Biomed Online. 2019; 39(5): 809-818. DOI:10.1016/j.rbmo.2019.07.027.

Urizar Arenaza I, Osinalde N, Akimov V, Puglia M, Candenas L, Pinto FM, et al. Phosphoproteomic and functional analyses reveal sperm-specific protein changes downstream of kappa opioid receptor in human spermatozoa. Mol Cell Proteomics. 2019; 18: 118-131. DOI:10.1074/mcp.RA118.001133.

Ibanez Perez J, Santos Zorrozua B, Lopez E, Irazusta J, Prieto B, Aparicio V, et al. Impact of physical activity on semen quality among men from infertile couples. Eur J Obstet Gynecol Reprod Biol. 2019; 237: 170-174. DOI:10.1016/j.ejogrb.2019.04.024.

Ibanez Perez J, Santos Zorrozua B, Lopez E, Matorras R, Garcia Orad A. An update on the implication of physical activity on semen quality: a systematic review and meta-analysis. Arch Gynecol Obstet. 2019; 299(4): 901-921. DOI:10.1007/s00404-019-05045-8.

Prieto Molano MB, Bregon M, Moragues D, Azkargorta M, Diez Zapirain M, Iglesias M, et al. Antibacterial and antifungal activity of the human endometrial fluid during the natural cycle. Hum Reprod. 2019; 34(1): 289-289

Olabarrieta E, Totorikaguena L, Agirregoitia N, Agirregoitia E. Implication of mu opioid receptor in the in vitro maturation of oocytes and its effects on subsequent fertilization and embryo development in mice. MOL REPROD DEV. 2019; 86(9): 1236-1244. DOI:10.1002/mrd.23248.

D'Angelo A, Panayotidis C, Amso N, Marci R, Matorras R, Onofriescu M, et al. Recommendations for good practice in ultrasound - oocyte pick-up: The practice. Hum Reprod. 2019; 34(1): 20-21

Urizar Arenaza I, Munoa Hoyos I, Gianzo M, Exposito A, Matorras R, Subiran N. The Mu- and Delta- opioid receptors modulate the human sperm acrosome reaction by blocking the calcium channels. Hum Reprod. 2019; 34(1): 155-156

Carrera M, Antonio Dominguez J, Perez de la Blanca E, Matorras R, Maria Gris J, Barrenetxea G, et al. SYSTEMATIC REVIEW AND CRITICAL APPRAISAL OF CURRENT ENDOMETRIOSIS GUIDELINES INCLUDING 2018 SPANISH ENDOMETRIOSIS GUIDELINE WITH FOUR EVALUATION METHODS. Fertil Steril. 2019; 112: 319-319. DOI:10.1016/j.fertnstert.2019.07.924.

Matorras R, Berreteaga L, Lainz L, Exposito A, Martinez L. Influence of Caesarean section-pregnancy interval on uterine rupture risk and IVF pregnancy rates: systematic review and mathematical modelling. Reprod Biomed Online. 2019; 39(5): 809-818. DOI:10.1016/j.rbmo.2019.07.027.

Carrano G, Paulone S, Lainz L, Sevilla M, Blasi E, Moragues M. Anti-Candida albicans germ tube antibodies reduce in vitro growth and biofilm formation of C. albicans. Rev Iberoam Micol. 2019; 36(1): 9-16. DOI:10.1016/j.riam.2018.07.005.

ESHRE Working Group on Ultrasound in A, D'Angelo A, Panayotidis C, Amso N, Marci R, Matorras R, et al. Recommendations for good practice in ultrasound: oocyte pick up † . Hum Reprod Open. 2019; 2019(4). DOI:10.1093/hropen/hoz025.

Pérez Ruiz I, Meijide S, Ferrando M, Larreategui Z, Ruiz Larrea MB, Ruiz Sanz JI. Ovarian stimulated cycles reduce protection of follicular fluid against free radicals. Free Radic Biol Med. 2019; 145: 330-335. DOI:10.1016/j.freeradbiomed.2019.10.004.

Diaz Nuñez M, Rabanal A, Expósito A, Ferrando M, Quintana F, Soria JM, et al. Recurrent Miscarriage and Implantation Failure of Unknown Cause Studied by a Panel of Thrombophilia Conditions: Increased Frequency of FXIII Val34Leu Polymorphism. J Reprod Infertil. 2019; 20(2): 76-82

Prieto I, Rubio Alarcon C, Garcia Gomez R, Berdun R, Manuel Portero R, Pamplona R, et al. Metabolic adaptations in spontaneously immortalized PGC-1 alpha knock-out mouse embryonic fibroblasts increase their oncogenic potential. Free Radic Biol Med. 2019; 139(1): 42-43

Malaina I, Aranburu L, Martinez L, Fernandez Llebrez L, Bringas C, De la Fuente IM, et al. Labor estimation by informational objective assessment (LEIOA) for preterm delivery prediction. Arch Gynecol Obstet. 2018; 297(5): 1213-1220. DOI:10.1007/s00404-018-4729-1.

Fernandez Alcober GA, Shumyatsky P. On bounded conciseness of words in residually finite groups. J Algebra. 2018; 500: 19-29. DOI:10.1016/j.jalgebra.2016.07.041.

Matorras R, Rubio K, Iglesias M, Vara I, Expósito A. Risk of pelvic inflammatory disease after intrauterine insemination: a systematic review. Reprod Biomed Online. 2018; 36(2): 164-171. DOI:10.1016/j.rbmo.2017.11.002.

Gomes Fernandes M, He N, Wang F, Van Iperen L, Eguizabal C, Matorras R, et al. Human-specific subcellular compartmentalization of P-element induced wimpy testis-like (PIWIL) granules during germ cell development and spermatogenesis. Hum Reprod. 2018; 33(2): 258-269. DOI:10.1093/humrep/dex365.

Azkargorta M, Escobes I, Iloro I, Osinalde N, Corral B, Ibanez Perez J, et al. Differential proteomic analysis of endometrial fluid suggests increased inflammation and impaired glucose metabolism in non-implantative IVF cycles and pinpoints PYGB as a putative implantation marker. Hum Reprod. 2018; 33(10): 1898-1906. DOI:10.1093/humrep/dey274.

Azkargorta M, Escobes I, Iloro I, Osinalde N, Corral B, Exposito A, et al. Differential proteomic analysis of endometrial fluid suggests increased inflammation and extracellular matrix remodeling in non-implantative IVF cycles. Hum Reprod. 2018; 33(1): 10-10

Matorras R, Quevedo S, Corral B, Prieto B, Exposito A, Mendoza R, et al. Proteomic pattern of implantative human endometrial fluid in in vitro fertilization cycles. Arch Gynecol Obstet. 2018; 297(6): 1577-1586. DOI:10.1007/s00404-018-4753-1.

Perez Ruiz I, Martinez G, Hernandez ML, Navarro R, Ferrando M, Larreategui Z, et al. Human granulosa cells express proteins of the paraoxonase family. Free Radic Biol Med. 2018; 120(1): 138-138. DOI:10.1016/j.freeradbiomed.2018.04.455.

Perez Ruiz I, Meijide S, Hernandez ML, Navarro R, Ferrando M, Larreategui Z, et al. Antioxidant status of human follicular fluid: natural versus controlled ovarian hyper-stimulated cycles. Free Radic Biol Med. 2018; 120(1): 62-62. DOI:10.1016/j.freeradbiomed.2018.04.206.

Iliuta F, Pijoan JI, Matorras R. Is the association of replete status in vitamin D with better results in IVF demonstrated?. Hum Reprod. 2018; 33(9): 1797-1797. DOI:10.1093/humrep/dey251.

Malaina I, Aranburu L, Martinez L, Fernandez Llebrez L, Bringas C, De la Fuente IM, et al. Labor estimation by informational objective assessment (LEIOA) for preterm delivery prediction. Arch Gynecol Obstet. 2018; 297(5): 1213-1220. DOI:10.1007/s00404-018-4729-1.

Lopez Cardona AP, Ibarra Lecue I, Laguna Barraza R, Perez Cerezales S, Uriguen L, Agirregoitia N, et al. Effect of chronic THC administration in the reproductive organs of male mice, spermatozoa and in vitro fertilization. Biochem Pharmacol. 2018; 157: 294-303. DOI:10.1016/j.bcp.2018.07.045.

Gianzo M, Urizar Arenaza I, Munoa Hoyos I, Larreategui Z, Garrido N, Casis L, et al. Human sperm testicular angiotensin-converting enzyme helps determine human embryo quality. Asian J Androl. 2018; 20(5): 498-498. DOI:10.4103/aja.aja_25_18.

Arenaza IU, Osinalde N, Akimov V, Munoa Hoyos I, Gianzo M, Ganzabal T, et al. SPANX A/D subfamily plays a key role in nuclear organisation, metabolism and flagellar-motility of human spermatozoa. Hum Reprod. 2018; 33(1): 58-58

Trepiana J, Ruiz Larrea MB, Ruiz Sanz JI. Unraveling the in vitro antitumor activity of Vismia baccifera against HepG2: role of hydrogen peroxide. Heliyon. 2018; 4(6). DOI:10.1016/j.heliyon.2018.e00675.

Mendoza R, Jáuregui T, Diaz Nuñez M, de la Sota M, Hidalgo A, Ferrando M, et al. Infertile Couples Prefer Twins: Analysis of Their Reasons and Clinical Characteristics Related to This Preference. J Reprod Infertil. 2018; 19(3): 167-173

Gianzo M, Urizar Arenaza I, Munoa Hoyos I, Larreategui Z, Irazusta J, Subiran N. Human Sperm Aminopeptidase N is related to embryo development and viability during ART. Hum Reprod. 2018; 33(1): 164-164

De la Fuente IM, Malaina I, Perez Samartin A, Dolores Boyano M, Perez Yarza G, Bringas C, et al. Dynamic properties of calcium-activated chloride currents in Xenopus laevis oocytes. Sci Rep. 2017; 7: 41791-41791. DOI:10.1038/srep41791.

Malaina I, Martinez L, Matorras R, Bringas C, Aranburu L, Fernandez Llebrez L, et al. Estimation of preterm labor immediacy by nonlinear methods. PLoS One. 2017; 12(6). DOI:10.1371/journal.pone.0178257.

Iniguez A, Sangroniz J. Words and characters in finite p-groups. J Algebra. 2017; 485: 230-246. DOI:10.1016/j.jalgebra.2017.05.017.

Lopez AV, Martinez L, Perez AV, Perez BV, Basova O. Combinatorics related to Higman's conjecture I: Parallelogramic digraphs and dispositions. Linear Alg Appl. 2017; 530: 414-444. DOI:10.1016/j.laa.2017.05.027.

Totorikaguena L, Olabarrieta E, Matorras R, Alonso E, Agirregoitia E, Agirregoitia N. Mu opioid receptor in the human endometrium: dynamics of its expression and localization during the menstrual cycle. Fertil Steril. 2017; 107(4). DOI:10.1016/j.fertnstert.2017.01.020.

Meijide S, Perez Ruiz I, Hernandez ML, Navarro R, Ferrando M, Larreategui Z, et al. Paraoxonase activities in human follicular fluid: role in follicular maturation. Reprod Biomed Online. 2017; 35(4): 351-362. DOI:10.1016/j.rbmo.2017.06.008.

Jimenez Moreno V, Agirregoitia E. Expression and localization of tubulin cofactors TBCD and TBCE in human gametes. Zygote. 2017; 25(3): 304-312. DOI:10.1017/S0967199417000144.

Malaina I, Martinez L, Matorras R, Bringas C, Aranburu L, Fernandez Llebrez L, et al. Estimation of preterm labor immediacy by nonlinear methods. PLoS One. 2017; 12(6). DOI:10.1371/journal.pone.0178257.

Trepiana J, Meijide S, Navarro R, Hernandez ML, Ruiz Sanz JI, Ruiz Larrea MB. Influence of oxygen partial pressure on the characteristics of human; hepatocarcinoma cells. Redox Biol. 2017; 12: 103-113. DOI:10.1016/j.redox.2017.02.004.

Matorras R, Exposito A, Larreategui Z, Lainz L, Quintana F, Mendoza R, et al. Obese women have a different polunsaturated fatty acid pattern in their oocytes. Hum Reprod. 2017; 32(1): 285-286

Urizar Arenaza I, Osinalde N, Gianzo M, Matorras R, Exposito A, Irazusta J, et al. Label-free phosphoproteomics reveals a novel calcium signaling pathway activated via kappa-opioid receptor in human spermatozoa. Hum Reprod. 2017; 32(1): 58-59

Lopez Cardona AP, Perez Cerezales S, Fernandez Gonzalez R, Laguna Barraza R, Pericuesta E, Agirregoitia N, et al. CB1 cannabinoid receptor drives oocyte maturation and embryo development via PI3K/Akt and MAPK pathways. FASEB J. 2017; 31(8): 3372-3382. DOI:10.1096/fj.201601382RR.

Stephen TL, Payne KK, Chaurio RA, Allegrezza MJ, Zhu HR, Perez Sanz J, et al. SATB1 Expression Governs Epigenetic Repression of PD-1 in Tumor-Reactive T Cells. Immunity. 2017; 46(1): 51-64. DOI:10.1016/j.immuni.2016.12.015.

Alonso I, Baroja A, Fernandez B, Vielba R, Elorriaga J, Perez Sanz J, et al. Changes in the expression of cyclin dependent kinase inhibitors during differentiation of immortalized fibroblasts into adipocytes. Int J Dev Biol. 2017; 61(1-2): 89-93. DOI:10.1387/ijdb.160416cd.

BURGOS SAN CRISTOBAL J, EXPOSITO NAVARRO A, MATORRAS WEINIG R. Impact on Pregnancy Rates of Endometrial Polyps First Suspected by Vaginal Ultrasound at Cycle Monitoring in Intrauterine Insemination Cycles. J Reprod Med. 2017

Fernandez Alcober GA, Thillaisundaram A. A NOTE ON AUTOMORPHISMS OF FINITE p-GROUPS. Glas Mat. 2016; 51(1): 117-123

Agirregoitia E, Totorikaguena L, Exposito A, Mendoza R, Matorras R, Agirregoitia N. Dynamic of expression and localization of cannabinoid-degrading enzymes FAAH and MGLL in relation to CB1 during meiotic maturation of human oocytes. Cell Tissue Res. 2016; 365(2): 393-401. DOI:10.1007/s00441-016-2381-2.

Urizar Arenaza I, Estomba H, Munoa Hoyos I, Matorras R, Esposito A, Candenas L, et al. The opioid peptide beta-endorphin stimulates acrosome reaction in human spermatozoa. Andrology. 2016; 4(1): 143-151. DOI:10.1111/andr.12133.

Anitua E, de la Fuente M, Ferrando M, Quintana F, Larreategui Z, Matorras R, et al. Biological effects of plasma rich in growth factors (PRGF) on human endometrial fibroblasts. Eur J Obstet Gynecol Reprod Biol. 2016; 206: 125-130. DOI:10.1016/j.ejogrb.2016.09.024.

Diez Alarcia R, Ibarra Lecue I, Lopez Cardona AP, Meana J, Gutierrez Adan A, Callado LF, et al. Biased Agonism of Three Different Cannabinoid Receptor Agonists in Mouse Brain Cortex. Front Pharmacol. 2016; 7. DOI:10.3389/fphar.2016.00415.

Merino S, Ibarluzea N, Maortua H, Prieto B, Rouco I, Lopez Ariztegui M, et al. Associated Clinical Disorders Diagnosed by Medical Specialists in 188 FMR1 Premutation Carriers Found in the Last 25 Years in the Spanish Basque Country: A Retrospective Study. Genes. 2016; 7(10). DOI:10.3390/genes7100090.

Lopez Cardona AP, Sanchez Calabuig MJ, Beltran Brena P, Agirregoitia N, Rizos D, Agirregoitia E, et al. Exocannabinoids effect on in vitro bovine oocyte maturation via activation of AKT and ERK1/2. Reproduction. 2016; 152(6): 603-612. DOI:10.1530/REP-16-0199.

Martinez L, Milanic M, Legarreta L, Medvedev P, Malaina I, de la Fuente IM. A combinatorial approach to the design of vaccines. J Math Biol. 2015; 70(6): 1327-1358. DOI:10.1007/s00285-014-0797-4.

Mendoza R, Perez S, de los Santos MJ, Larreategui Z, Ayerdi F, Exposito A, et al. Congenital Malformations, Chromosomal Abnormalities and Perinatal Results in IVF/ICSI Newborns Resulting from Very Poor Quality Embryos: A Case-Control Study. GynecolObstetInvest. 2015; 79(2): 83-89. DOI:10.1159/000353605.

Agirregoitia E, Ibarra Lecue I, Totorikaguena L, Mendoza R, Exposito A, Matorras R, et al. Dynamics of expression and localization of the cannabinoid system in granulosa cells during oocyte nuclear maturation. Fertil Steril. 2015; 104(3): 753-760. DOI:10.1016/j.fertnstert.2015.06.013.

Crisol Ortiz L, Matorras R, Aspichueta F, Exposito A, Ruiz Larrea MB, Quintana F, et al. Low values of n-3 polyunsaturated fatty acids in sperm cells are associated to lower fertilization rates in IVF cycles. Hum Reprod. 2015; 30(1): 152-152

Urizar I, Munoa I, Gianzo M, Estomba H, Matorras R, Exposito A, et al. The Kappa-opioid receptor modulates the human sperm capacitation and acrosome reaction. Hum Reprod. 2015; 30(1): 174-175

Lizcano LJ, Siles M, Trepiana J, Luisa Hernandez M, Navarro R, Begona Ruiz Larrea M, et al. Piper and Vismia Species from Colombian Amazonia Differentially Affect Cell Proliferation of Hepatocarcinoma Cells. Nutrients. 2015; 7(1): 179-195. DOI:10.3390/nu7010179.

Management of women with premature ovarian insufficiency. Management of women with premature ovarian insufficiency. Guías de Práctica Clínica. 2015

De la Fuente IM, Cortés JM, Valero E, Desroches M, Rodrigues S, Malaina I, et al. On the Dynamics of the Adenylate Energy System: Homeorhesis vs Homeostasis. PLoS One. 2014; 9(10). DOI:10.1371/journal.pone.0108676.

Fernandez Alcober GA, Morigi M, Shumyatsky P. Procyclic coverings of commutators in profinite groups. Arch Math. 2014; 103(2): 101-109. DOI:10.1007/s00013-014-0672-y.

Fernandez Alcober GA, Legarreta L, Tortora A, Tota M. A restriction on centralizers in finite groups. J Algebra. 2014; 400: 33-42. DOI:10.1016/j.jalgebra.2013.10.032.

Matorras R, Otero B, Mendoza R, Exposito A, Luis De Pablo J, Larreategui Z, et al. Quality of additional embryos transferred on pregnancy outcomes in IVF: predictions using a mathematical approach. Reprod Biomed Online. 2014; 29(2): 200-208. DOI:10.1016/j.rbmo.2014.04.020.

Matorras R, Aparicio V, Corcostegui B, Prieto B, Mendoza R, Ramon O, et al. Failure of intrauterine insemination as rescue treatment in low responders with adequate HCG timing with no oocytes retrieved. Reprod Biomed Online. 2014; 29(5): 634-639. DOI:10.1016/j.rbmo.2014.07.020.

Ajuria Morentin I, Mar Medina C, Bereciartua Urbieta E, Aguirre Larracoechea U, Quintana Lopez JM, Ruiz Larrea MB. Determination of Reference Values for Serum Folate and Vitamin B12 Using Three Different Immunoassays: Is it Worth Making an Effort to Produce them in Our Laboratory?. Clin Lab. 2014; 60(7): 1135-1143. DOI:10.7754/Clin.Lab.2013.130729.

Matorras R, Exposito A, Mendoza R, Quevedo S, Gomez Picado O, Larrategui Z, et al. Effect of the quality of the additional embryos on the pregnancy and multiple pregnancy rates in IVF cycles: predictions using mathematical formulae and nomograms. Hum Reprod. 2014; 29(1): 106-106

Crisol L, Aspichueta F, Matorras R, Exposito A, Ruiz Larrea MB, Quintana F, et al. Variations in sperm fatty acids profiles after capacitation process in normal and pathological semen samples. Hum Reprod. 2014; 29(1): 121-122

Mendoza M, Jauregui T, de la Sota M, Hidalgo A, Ferrando M, Matorras R. Assisted Reproductive couples preferred twins: a questionnaire study. Hum Reprod. 2014; 29(1): 272-273

Prieto B, Ramon O, Brouard I, Exposito A, Mendoza R, Quevedo S, et al. Influence of endometrial polyp-like lesions detected during ultrasound at ovarian stimulation on IUI results. Hum Reprod. 2014; 29(1): 360-361

Susana M, Irantzu PR, Luisa HM, Marcos F, Zaloa L, Ignacio RSJ, et al. Characterization of the paraoxonase system in follicular fluid of women subjected to an ovarian stimulation cycle. Free Radic Biol Med. 2014; 75(1): 41-42. DOI:10.1016/j.freeradbiomed.2014.10.793.

Susana M, Luisa HM, Rosaura N, Zaloa L, Marcos F, Ignacio RSJ, et al. Glutathione S-transferase activity in follicular fluid from women undergoing ovarian stimulation: role in maturation. Free Radic Biol Med. 2014; 75(1): 41-41. DOI:10.1016/j.freeradbiomed.2014.10.792.

Lopez de Vergara O, Pablos R, Ruiz Sanz MB, Ruiz Larrea JI, Navarro R. Characterization of the NF-kappa B signaling triggered by doxorubicin. Free Radic Biol Med. 2014; 75(1): 38-38. DOI:10.1016/j.freeradbiomed.2014.10.784.

Matorras R, Andrés M, Mendoza R, Prieto B, Pijoan JI, et al. Prevention of ovarian hyperstimulation syndrome in GnRH agonist IVF cycles in moderate risk patients: randomized study comparing hydroxyethyl starch versus cabergoline and hydroxyethyl starch. Eur J Obstet Gynecol Reprod Biol. 2013;170:439-43. FI: 1,843(Q2)

Matorras R, Rabanal A, Prieto B, Diez S, Brouard I, Mendoza R, et al. Hysteroscopic hydrosalpinx occlusion with Essure device in IVF patients when salpingectomy or laparoscopy is contraindicated. Eur J Obstet Gynecol Reprod Biol. 2013;169:54-9. FI: 1,843(Q2)

Tejada MI, Maortua H, Mendoza R, Prieto B, Martinez-Bouzas C, Diez-Zapirain M, et al. Study of triple CGG repeats (FMR1 gene) in 41 patients with a reduced ovarian response to gonadotropin stimulation: no correlation found with four ovarian parameters. Hum Reprod. 2013;28:241-2. FI: 4,670(Q1) (Meeting Abstract)

Perez-Sanz J, Matorras R, Arluzea J, Bilbao J, Gonzalez-Santiago N, Yeh N, et al. P27kip1 mutant mice displays an increased number of multioocyte follicles(mofs): presumable role of granulosa cells. Hum Reprod. 2013;28:1023-30. FI: 4,670(Q1)

Fermin A, Crisol L, Exposito A, Prieto B, Mendoza R, Matorras R. Influence of the fsh/lh ratio in ovarian stimulation in ivf results in women aged over 35 years: a randomized study. Hum Reprod. 2013;28:349. FI: 4,670(Q1). (Meeting Abstract)

Pérez-Sanz J, Arluzea J, Matorras R, González-Santiago N, Bilbao J, Yeh N, et al. Increased number of multi-oocyte follicles (MOFs) in juvenile p27Kip1 mutant mice: potential role of granulosa cells. Hum Reprod. 2013;28:1023-30. FI: 4,670(Q1). (Meeting Abstract)

Tesis del grupo

Autor/a: Itziar Urizar Arenaza. Título: Proteomic study of sperm-specific molecular mechanisms in human spermatozoa underlying sperm fertility/Giza espermatozoideen ahalmen ugalkorra erregulatzen duten mekanismo molekular espezifikoen azterketa proteomikoa. Director/a: Dr. Jon Irazusta Astiazaran, Dra. Nerea Subiran Ciudad.

Autor/a: Iraia Muñoa Hoyos. Título: Study of the epigenetic cellular memory induced by morphine: a next generation sequencing approach/Morfinak eragindako zelulen arteko memoria epigenetikoaren azterketa, bigarren belaunaldiko sekuentziazioaren bitartez. Director/a: Dr. Jon Irazusta Astiazaran, Dra. Nerea Subiran Ciudad.

Autor/a: Irantzu Pérez Ruiz. Título: Controlled ovarian hyperstimulation cycle: alterations in redox status of the follicular fluid.. Director/a: Dra. María Begoña Ruiz Larrea, Dr. José Ignacio Ruiz Sanz.

Autor/a: María Victoria Aparicio Prieto. Título: "Fragmentación del ADN espermático y su relación con el metabolismo peptídico". Directores/as: Dr. Luis Casis Saenz, Dra. Nerea Subirán Ciudad.

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