Multidisciplinar médico-quirúrgico de patología respiratoria
Multidisciplinar médico-quirúrgico de patología respiratoria
Actividades del grupo
Las enfermedades crónicas suponen ya, y van a suponer en un futuro muy próximo, cada vez una carga mayor para la sociedad y el sistema sanitario. La EPOC es un proceso altamente prevalente que ya supone un alto coste especialmente en lo referente a las hospitalizaciones. La telemedicina se ha demostrado útil para el control de otras enfermedades. También en la EPOC puede ser un instrumento que ayude a un adecuado y coste-efectivo control de estos pacientes. Se propone un estudio de cohortes, longitudinal, prospectivo pre y post-intervención, coordinado y multicéntrico con grupo de intervención (sub-proyecto 1) y grupo control externo (sub-proyecto 2). Al cabo de un año el grupo control pasará tambien a formar parte del grupo de intervención. Se recogerán datos retrospectivamente del año anterior al comienzo del estudio en ambos centros. Se medirán variables clínicas y fisiológicas, de calidad de vida y satisfacción del paciente al inicio, al cabo de un año y al final del estudio. Se pondrá en marcha un dispositivo de telemonitorización a distancia, recogiéndose diariamente una serie de variables fisiológicas y un cuestionario clínico. Se establecerá un sistema de alertas y de respuestas. Estas respuestas estarán coordinadas entre la asistencia priMaría y la especializada. Resultados: ingresos hospitalarios, complicaciones, valoraciones en servicios de urgencias, evolución de la calidad de vida, satisfacción del paciente y costes en ambos grupos. Análisis estadístico: se compararán los resultados a medir entre los dos grupos (intervención /control) y entre antes-después de la intervención en cada centro. En el análisis multivariante se emplearán modelos de regresión logística y la regresión de Cox condicional. Para la comparación pre-post se emplearán modelos GEE.
Infecciones Respiratorias. Gripe. | Responsable: Rafael Zalacain Jorge
Colaboradores: Luis Alberto Ruiz Iturriaga, Ainhoa Gómez Bonilla, José María Antoñana Larrieta.
La neumonía adquirida en la comunidad (NAC) con una incidencia anual que oscila entre el 5 y el 11% de la población adulta constituye una de las principales causa de ingreso hospitalario en los países occidentales especialmente entre los pacientes ancianos con múltiples comorbilidades. La mortalidad asociada a esta entidad en los pacientes ingresados oscila entre el 5 al 50% dependiendo de la gravedad del cuadro.
En nuestro hospital una media de 350 pacientes ingresan anualmente en el Servicio de Neumología por esta entidad que representa la tercera causa de ingreso hospitalario urgente. Aproximadamente un 11 % de estos pacientes van a requerir de asistencia en el Servicio de Medicina Intensiva.
En los últimos años nuestro grupo ha venido participando en la elaboración y desarrollo de varios proyectos multicéntricos relacionados con el tema y que ha dado como fruto la publicación de varios artículos originales en revistas de reconocido prestigio internacional. Actualmente estamos interesados en el estudio de diversos aspectos relacionados con la epidemiología de las NAC bacteriémicas así como en el papel que las diferentes comorbilidades tienen en la presentación clínica y en el pronóstico de los pacientes ingresados con esta entidad.
Durante el año 2009 y coincidiendo con la epidemia por el virus A1H1 nuestro Servicio ha participado en el Proyecto de Investigación de la gripe estacional 2010-2011 patrocinado por el Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación (MICINN), CIBERES, SeMycuc ( Sociedad Española de Medicina Intensiva y Unidades Coronarias).
Enfermedad Tromboembólica Venosa. Hipertensión Pulmonar | Responsable: Fernando Uresandi Romero
Colaboradores: Luis Alberto Ruiz
Patología Respiratoria del Sueño. Insuficiencia Respiratoria. Vmni | Responsables: José Amilibia Alonso
Colaboradores: Valentín Cabriada Nuño; Milagros Iriberri Pascual; Carmen Jaca Michelena; Amaia Urrutia Gajate; Ruth Diez Arnesto
El Síndrome de Apnea-Hipopnea del Sueño (SAHS) es una entidad muy prevalente, que puede llegar a afectar hasta el 5% de la población, y que ocasiona en los afectados un grave deterioro de su calidad de vida. Además está relacionado con una importante morbimortalidad cardiovascular y con la génesis de accidentes de tráfico. La carga sanitaria y económica que todo esto implica se ve aún más potenciada por los costes que genera su correcto diagnóstico (asociado con frecuencia a considerables listas de espera) y tratamiento (principalmente el uso de CPAP). Nuestro grupo está especialmente interesado en profundizar en aspectos eminentemente prácticos que permitan mejorar, simplificando y haciéndolo más ágil, el proceso diagnóstico y terapeútico de esta enfermedad, así como en el desarrollo y correcta indicación de otras posibilidades terapeúticas (terapias posturales, cirugía, dispositivos de avance mandibular…).
Por otro lado también estamos trabajando en conseguir un conocimiento más detallado de las implicaciones cardiovasculares que este síndrome implica, y de las posibilidades terapeúticas que de ellas se derivan en patologías de tanta importancia como el Síndrome Coronario Agudo.
Nuestro grupo ha desarrollado también una importante actividad relacionada con la Ventilación Mecánica No Invasiva, modalidad terapeútica de crecimiento exponencial en el campo de la Neumología en los últimos años. Esta actividad se ha producido tanto en lo que atañe al tratamiento de la Insuficiencia Respiratoria Hipercápnica Crónica de diversos orígenes y a los trastornos respiratorios del sueño asociados (hipoventilación alveolar nocturna…), como en lo que respecta al tratamiento del Fracaso Ventilatorio Agudo.
Finalmente debemos mencionar nuestro interés en la aplicación de otras técnicas novedosas para el manejo de la Insuficiencia Respiratoria Hipoxémica, como puede ser la CPAP o la Oxigenoterapia de Alto Flujo, con humidificación activa.
Fibrosis Quística| Responsables: Baranda F; Vazquez C, Gómez Bonilla A, Gómez Crespo B, Martínez Ruiz Nagore.
Los miembros de la Unidad de fibrosis quística (FQ) del Hospital Universitario de Cruces tienen acreditada una dilatada experiencia clínica e investigadora en los distintos aspectos de la enfermedad como son el Screening, protocolo diagnostico, control evolutivo y terapéutica de los pacientes afectos de FQ de más de 30 años. El HU de Cruces es el hospital de referencia de esta enfermedad para la totalidad del País Vasco, Navarra, Cantabria y Castilla-León. En la actualidad la unidad controla un total de 185 pacientes.
E l Dr. Félix Baranda, responsable de la Unidad FQ de adultos y el Dr. Carlos Vázquez, responsable de la Unidad FQ pediátrica; forman parte activa de las Sociedad Española de Fibrosis Quística participando en los consensos de diagnóstico y tratamiento.
En la Unida FQ de adultos, se controlan paralelamente un grupo de 40 pacientes afectos de Bronquiectasias no FQ colonizados por microorganismos multirresistentes y que requieren de una valoración diagnostica, seguimiento y tratamiento multicomplejo específico. La experiencia en esta área de la Neumología queda reflejada en la elaboración de las monografías del diagnóstico y tratamiento mediante terapia antibiótica inhalada.
EPOC. Sístemas de Telemedicina (Futura Línea de investigación)| Responsable: Dra Milagros Iriberri Pascual
Colaboradores:Beatriz Gómez Crespo, Valentín Cabriada Nuño, Felix María Baranda García, Isabel López Aranaga.
Coordinador/a del grupo
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Luis Alberto Ruiz Iturriaga
Coordinador del grupo
luisalberto.ruiziturriaga@osakidetza.eus
CV resumen
Miembros del grupo
Publicaciones del grupo
Ruiz LA, Serrano L, Perez S, Castro S, Urrutia A, Uranga A, et al. Impact of severe lymphopenia on the early prediction of clinical outcome in hospitalized patients with pneumococcal community-acquired pneumonia. Infection. 2023; 51(5): 1319-1327. DOI:10.1007/s15010-023-01984-2.
Cilloniz C, Ferrer M, Pericas JM, Serrano L, Méndez R, Gabarrús A, et al. Validation of IDSA/ATS Guidelines for ICU Admission in Adults Over 80 Years Old With Community-Acquired Pneumonia. Arch Bronconeumol. 2023; 59(1): 19-26. DOI:10.1016/j.arbres.2022.08.012.
Zapater A, Gracia Lavedan E, Torres G, Minguez O, Pascual L, Cortijo A, et al. Proteomic profiling for prediction of recurrent cardiovascular event in patients with acute coronary syndrome and obstructive sleep apnea: A post-hoc analysis from the ISAACC study. Biomed Pharmacother. 2023; 158. DOI:10.1016/j.biopha.2022.114125.
Moreno Torres V, Martin Iglesias D, Vivero F, Gonzalez Echavarri C, Garcia Moyano M, Enghelmayer J, et al. Intravenous cyclophosphamide improves functional outcomes in interstitial lung disease related to idiopathic inflammatory myopathies. Semin Arthritis Rheum. 2023; 59: 152164-152164. DOI:10.1016/j.semarthrit.2023.152164.
Perez de Llano L, Marina Malanda N, Urrutia I, Martinez Moragon E, Gullon Blanco JA, Diaz Campos R, et al. Factors associated with suboptimal response to monoclonal antibodies in severe asthma. Allergy. 2023; 78(8): 2305-2310. DOI:10.1111/all.15693.
Giron RM, Carrasco Hernandez L, Pelaez A, Gomez Bonilla A, Symkevi working G. Influence on sputum microbiology with CFTR modulator (tezacaftor-ivacaftor) in adult patients with cystic fibrosis: Multicenter study. Enferm Infecc Microbiol Clin (Engl Ed). 2023; 41(3): 193-195. DOI:10.1016/j.eimce.2022.05.018.
Esteban C, Anton Ladislao A, Aramburu A, Chasco L, Orive M, Tabernero E, et al. Change in physical activity related to admission for exacerbation in COPD patients. Respir Med. 2023; 212: 107236-107236. DOI:10.1016/j.rmed.2023.107236.
Hayet Otero M, Garcia F, Lee D, Martinez Minaya J, Espana Yandiola PP, Urrutia Landa I, et al. Extracting relevant predictive variables for COVID-19 severity prognosis: An exhaustive comparison of feature selection techniques. PLoS One. 2023; 18(4): 284150-284150. DOI:10.1371/journal.pone.0284150.
Quintana J, Anton Ladislao A, Orive M, Aramburu A, Iriberri M, Sanchez R, et al. Correction to: Predictors of short-term COPD readmission (vol 17, pg 1481, 2022). Intern Emerg Med. 2023; 18(5): 1609-1609. DOI:10.1007/s11739-023-03346-0.
Castro S, Pedrero S, Ruiz LA, Serrano L, Zalacain R, Perez Fernandez S, et al. High-flow nasal cannula oxygen therapy for the treatment of acute respiratory failure secondary to SARS-CoV-2 pneumonia out of ICU. Clin Respir J. 2023; 17(9): 905-914. DOI:10.1111/crj.13679.
Bronte O, Garcia F, Lee D-J, Urrutia I, Uranga A, Nieves M, et al. Impact of outdoor air pollution on severity and mortality in COVID-19 pneumonia. Sci Total Environ. 2023; 894. DOI:10.1016/j.scitotenv.2023.164877.
Serrano L, Ruiz LA, Perez Fernandez S, Espana PP, Gomez A, Gonzalez B, et al. Short- and long-term prognosis of patients with community-acquired Legionella or pneumococcal pneumonia diagnosed by urinary antigen testing. Int J Infect Dis. 2023; 134: 106-113. DOI:10.1016/j.ijid.2023.05.065.
Mondejar Lopez P, Moreno Galarraga L, de Manuel Gomez C, Blitz Castro E, Bravo Lopez M, Gartner S, et al. SARS-CoV-2 infection in children with cystic fibrosis: A cross-sectional multicenter study in Spain. New waves, new knowledge. Pediatr Pulmonol. 2023. DOI:10.1002/ppul.26644.
Tabernero Huguet E, Leal Arranz MV, Garcia Fuertes JA, Santos Zorrozua B, Ortiz Laza N, Ortiz de Urbina B, et al. Clinical and Treatment Outcome Differences Between the Most Common Nontuberculous Mycobacteria (NTM) in the Basque Country. Arch Bronconeumol. 2023; 59(11): 765-767. DOI:10.1016/j.arbres.2023.07.021.
Pinilla L, Esmaeili N, Labarca G, Martinez Garcia MA, Torres G, Gracia Lavedan E, et al. Hypoxic burden to guide CPAP treatment allocation in patients with obstructive sleep apnoea: a Post-hoc study of the ISAACC trial. Eur Resp J. 2023. DOI:10.1183/13993003.00828-2023.
Rubio MC, Lopez Campos JL, Miravitlles M, de la Rosa FJM, Perez JMH, Martinez CM, et al. COVID-19's impact on care practice for alpha-1-antitrypsin deficiency patients. BMC Health Serv Res. 2023; 23(1). DOI:10.1186/s12913-023-09094-3.
Solelhac G, Sánchez Torre M, Blanchard M, Berger M, Hirotsu C, Imler T, et al. Pulse Wave Amplitude Drops Index: A Biomarker of Cardiovascular Risk in Obstructive Sleep Apnea. Am J Respir Crit Care Med. 2023; 207(12): 1620-1632. DOI:10.1164/rccm.202206-1223OC.
Gomez Larrauri A, Gangoiti P, Camacho L, Presa N, Martin C, Gomez Munoz A. Phosphatidic Acid Stimulates Lung Cancer Cell Migration through Interaction with the LPA1 Receptor and Subsequent Activation of MAP Kinases and STAT3. Biomedicines. 2023; 11(7). DOI:10.3390/biomedicines11071804.
Rojo MA, Goiria Z, Domingos S, Ibanez J, Ruiz LA. Dyspnoea after epileptic seizures: beyond aspiration pneumonia. Intern Emerg Med. 2023. DOI:10.1007/s11739-023-03352-2.
Martinez Menaca A, Barbero Herranz E, Munoz Esquerre M, Marin Oto M, Garcia Moyano M, Cascon Hernandez JA, et al. [Highlights of the 55th SEPAR Congress]. Open Respir Arch. 2023; 5(1): 100216-100216. DOI:10.1016/j.opresp.2022.100216.
Furundarena Padrones L, Cabriada Nuno V, Brunso Casellas J, Garcia Fernandez RI, Castro Quintas S, Santos Zorrozua B, et al. Correlation between polysomnographic parameters and volumetric changes generated by maxillomandibular advancement surgery in patients with obstructive sleep apnea: a fluid dynamics study. J Clin Sleep Med. 2023. DOI:10.5664/jcsm.10874.
Esteban C, Anton Ladislao A, Aramburu A, Chasco L, Orive M, Sobradillo P, et al. Physical activity and sedentary behaviour in patients admitted with COPD: Associated factors. Respir Med Res. 2023; 84: 101052-101052. DOI:10.1016/j.resmer.2023.101052.
Cushen B, Koh MS, Tran TN, Martin N, Murray R, Uthaman T, et al. Adult Severe Asthma Registries: A Global and Growing Inventory. Pragmatic And Observational Research. 2023; 14: 127-147. DOI:10.2147/POR.S399879.
Mendez R, Gonzalez Jimenez P, Latorre A, Mengot N, Zalacain R, Ruiz LA, et al. Is the long-term mortality similar in COVID-19 and community-acquired pneumonia?. Front Med. 2023; 10. DOI:10.3389/fmed.2023.1236142.
Candel FJ, Salavert M, Basaras M, Borges M, Canton R, Cercenado E, et al. Ten Issues for Updating in Community-Acquired Pneumonia: An Expert Review. J Clin Med. 2023; 12(21). DOI:10.3390/jcm12216864.
Sobradillo Ecenarro P, Iriberri Pascual MM, Tabernero Huguet EM. [GOLD 2023: News with Clinical Implications?]. Open Respir Arch. 2023; 5(3). DOI:10.1016/j.opresp.2023.100258.
Mondejar Lopez P, Zolin A, Garcia Marcos PW, Pastor Vivero MD, Rosa Silvestre M, Sanchez Martinez FD, et al. Geographic distribution and phenotype of European people with cystic fibrosis carrying A1006E mutation. Respir Med. 2022; 192. DOI:10.1016/j.rmed.2022.106736.
Camacho L, Ouro A, Gomez Larrauri A, Carracedo A, Gomez Munoz A. Implication of Ceramide Kinase/C1P in Cancer Development and Progression. Cancers (Basel). 2022; 14(1). DOI:10.3390/cancers14010227.
Torrent Vernetta A, Gaboli M, Castillo Corullon S, Mondejar Lopez P, Santiago VS, Costa Colomer J, et al. Incidence and Prevalence of Children's Diffuse Lung Disease in Spain. Arch Bronconeumol. 2022; 58(1): 22-29. DOI:10.1016/j.arbres.2021.06.001.
Quintana JM, Anton Ladislao A, Orive M, Aramburu A, Iriberri M, Sánchez R, et al. Predictors of short-term COPD readmission. Intern Emerg Med. 2022; 17(5): 1481-1490. DOI:10.1007/s11739-022-02948-4.
Rodriguez C, Jara Palomares L, Tabernero E, Tenes A, Gonzalez S, Briceno W, et al. Adjusted D-dimer cutoff levels to rule out pulmonary embolism in patients hospitalized for COPD exacerbation: results from the SLICE trial. Thromb J. 2022; 20(1). DOI:10.1186/s12959-022-00368-0.
Perez de Llano L, Dacal Rivas D, Marina Malanda N, Plaza Moral V, Gullon Blanco JA, Munoz Esquerre M, et al. The Response to Biologics is Better in Patients with Severe Asthma Than in Patients with Asthma-COPD Overlap Syndrome. J ASTHMA ALLERGY. 2022; 15: 363-369. DOI:10.2147/JAA.S338467.
de Llano L, Cosio BG, Astiarraga IL, Campos GS, Alonso M, Malanda NM, et al. Asthma Control in Patients with Severe Eosinophilic Asthma Treated with Reslizumab: Spanish Real-Life Data. J ASTHMA ALLERGY. 2022; 15: 79-88. DOI:10.2147/JAA.S340562.
Serrano Fernandez L, Ruiz Iturriaga LA, Zalacain Jorge R. Bacteremic pneumococcal pneumonia: arrhythmogenic disease. Rev Esp Quim. 2022; 35 Suppl 1: 111-113. DOI:10.37201/req/s01.23.2022.
Menendez R, Mendez R, Gonzalez Jimenez P, Zalacain R, Ruiz LA, Serrano L, et al. Early recognition of low-risk SARS-CoV-2 pneumonia: A model validated with initial data and IDSA/ATS minor criteria. Chest. 2022; 162(4): 768-781. DOI:10.1016/j.chest.2022.05.013.
Gullon Blanco JA, Rodrigo Sanz T, Tabernero Huguet E, Sabria Mestres J, Anibarro L, Villanueva Montes M, et al. [Translated article] Tuberculosis contacts tracing in Spain: Cost analysis. Arch Bronconeumol. 2022; 58(5): 448-450. DOI:10.1016/j.arbres.2021.09.021.
Gullon Blanco JA, Rodrigo Sanz T, Tabernero Huguet E, Sabria Mestres J, Anibarro L, Villanueva Montes M, et al. Tuberculosis Contacts Tracing in Spain: Cost Analysis. Arch Bronconeumol. 2022; 58(5): 448-450. DOI:10.1016/j.arbres.2021.09.016.
Sanz F, Iturriaga LR, Clemente MG, Espana P, Serrano L, Collado NC, et al. Capsular Polysaccaride Thickness Is an Essential Factor for the Antibiotic Response in Bacteremic Pneumococcal Pneumonia. Am J Respir Crit Care Med. 2022; 205
Lopez I, Aguinagalde B, Urreta I, Royo I, Bolufer S, Sanchez L, et al. Results in mediastinal lymph node staging of surgical lung cancer: Data from the prospective cohort of the Spanish Video-Assisted Thoracic Surgery Group. Cir Esp (Engl Ed). 2022. DOI:10.1016/j.cireng.2022.06.006.
Aguado C, Chara L, Antonanzas M, Matilla Gonzalez JM, Jimenez U, Hernanz R, et al. Neoadjuvant treatment in non-small cell lung cancer: New perspectives with the incorporation of immunotherapy. World J Clin Oncol. 2022; 13(5): 314-322. DOI:10.5306/wjco.v13.i5.314.
Rubio MC, Lopez Campos JL, Alonso JLI, Pitarch DM, Pascual MI, Navarrete BA, et al. Consensus on the Management of the COPD Patient in the COVID-19 Setting: COPD Forum Working Group. Arch Bronconeumol. 2022. DOI:10.1016/j.arbres.2022.04.011.
Gomez de Antonio D, Crowley Carrasco S, Romero Roman A, Royuela A, Calle AS, Obiols Fornell C, et al. [Translated article] Surgical Risk Following Anatomic Lung Resection in Thoracic Surgery: A Prediction Model Derived From a Spanish Multicenter Database. Arch Bronconeumol. 2022; 58(5): 398-405. DOI:10.1016/j.arbres.2021.01.039.
Luis Izquierdo J, Casanova C, Celli B, Santos S, Sibila O, Sobradillo P, et al. The 7 Cardinal Sins of COPD in Spain. Arch Bronconeumol. 2022; 58(6): 498-503. DOI:10.1016/j.arbres.2021.12.008.
Carr SB, McClenaghan E, Elbert A, Faro A, Cosgriff R, Abdrakhmanov O, et al. Factors associated with clinical progression to severe COVID-19 in people with cystic fibrosis: A global observational study. J Cyst Fibros. 2022; 21(4): 221-231. DOI:10.1016/j.jcf.2022.06.006.
Zapater A, Solelhac G, Sanchez Torre A, Gracia Lavedan E, Benitez ID, Torres G, et al. Respiratory Polygraphy Patterns and Risk of Recurrent Cardiovascular Events in Patients With Acute Coronary Syndrome. Front Med (Lausanne). 2022; 9: 870906-870906. DOI:10.3389/fmed.2022.870906.
Tabernero E, Rodrigo T, Garros J, Altube L, Garay E, Medina J-F, et al. TB in the elderly: clinical features and outcomes. Int J Tuberc Lung Dis. 2022; 26(9): 842-849. DOI:10.5588/ijtld.22.0010.
Cilloniz C, Ferrer M, Pericas JM, Serrano L, Mendez R, Gabarrus A, et al. Validation of IDSA/ATS Guidelines for ICU Admission in Adults Over 80 Years Old With Community-acquired Pneumonia. Arch Bronconeumol. 2022. DOI:10.1016/j.arbres.2022.08.010.
Serrano L, Ruiz LA, Perez S, Espana PP, Gomez A, Cilloniz C, et al. ESTIMATING THE RISK OF BACTERAEMIA IN HOSPITALISED PATIENTS WITH PNEUMOCOCCAL PNEUMONIA. J Infect. 2022; 85(6): 644-651. DOI:10.1016/j.jinf.2022.09.017.
Frutos MA, Crespo M, de la Oliva Valentin M, Alonso Melgar A, Alonso J, Fernandez C, et al. Guidelines for living donor kidney transplantation. Nefrologia. 2022; 42: 1-128. DOI:10.1016/j.nefro.2021.10.002.
Carrasco Hernandez L, Giron Moreno RM, Pelaez A, Gomez Bonilla A, Gomez Crespo B, Diab Caceres L, et al. Real Life With Tezacaftor and Ivacaftor in Adult Patients With Cystic Fibrosis: Spanish Multicenter Study. Arch Bronconeumol. 2022; 58(9): 672-674. DOI:10.1016/j.arbres.2022.06.003.
Sanchez Torre M, Gracia Lavedan E, Benitez ID, Zapater A, Torres G, Sanchez Torre A, et al. Long-Term Effect of Obstructive Sleep Apnea and Continuous Positive Airway Pressure Treatment on Blood Pressure in Patients with Acute Coronary Syndrome: A Clinical Trial. Ann Am Thorac Soc. 2022; 19(10): 1750-1759. DOI:10.1513/AnnalsATS.202203-260OC.
Goena C, Arana X, Villanueva I, Solla I, Rengel A, Manas L, et al. Heart failure with preserved ejection fraction in the elderly: when to suspect transthyrretin cardiac amyloidosis?. Eur J Heart Fail. 2022; 24: 33-33
Arana X, Goena C, Villanueva I, Solla I, Rengel A, Manas L, et al. Prognostic impact of diagnosis of transthyretin cardiac amyloidosis. Eur J Heart Fail. 2022; 24: 71-71
Aguado C, Maestre UJ, Mielgo Rubio X. Neoadjuvant immunotherapy in non-small-cell lung cancer: Times are changing-and fast. World J Clin Oncol. 2022; 13(9): 758-761. DOI:10.5306/wjco.v13.i9.758.
Sesma J, Bolufer S, Garcia Valentin A, Embun R, Lopez IJ, Moreno Mata N, et al. Thoracoscopic segmentectomy versus lobectomy: Apropensity score-matched analysis. Jtcvs Open. 2022; 9: 268-278. DOI:10.1016/j.xjon.2022.01.009.
Bikdeli B, Caraballo C, Trujillo Santos J, Galanaud JP, di Micco P, Rosa V, et al. Clinical Presentation and Short- and Long-term Outcomes in Patients With Isolated Distal Deep Vein Thrombosis vs Proximal Deep Vein Thrombosis in the RIETE Registry. JAMA Cardiol. 2022; 7(8): 857-865. DOI:10.1001/jamacardio.2022.1988.
Trujillo Santos J, Farge Bancel D, Pedrajas JM, Gomez Cuervo C, Ballaz A, Braester A, et al. Enoxaparin versus dalteparin or tinzaparin in patients with cancer and venous thromboembolism: The RIETECAT study. Res Pract Thromb Haemost. 2022; 6(4). DOI:10.1002/rth2.12736.
Cubillos Zapata C, Martinez Garcia MA, Diaz Garcia E, Garcia Tovar S, Campos Rodriguez F, Sanchez Torre M, et al. Obstructive sleep apnea is related to melanoma aggressiveness through paraspeckle protein-1 upregulation. Eur Resp J. 2022. DOI:10.1183/13993003.00707-2022.
Gil Redondo R, Conde R, Bizkarguenaga M, Bruzzone C, Lain A, Gonzalez Valle B, et al. An NMR-Based Model to Investigate the Metabolic Phenoreversion of COVID-19 Patients throughout a Longitudinal Study. Metabolites. 2022; 12(12). DOI:10.3390/metabo12121206.
Antonia Ramon M, Esteban C, Ortega F, Cebollero P, Carrascosa I, Martinez Gonzalez C, et al. Discriminant Validity of a Single Clinical Question for the Screening of Inactivity in Individuals Living with COPD. Int J Chronic Obstr Pulm Dis. 2022; 17: 3033-3044. DOI:10.2147/COPD.S378758.
Melchio R, Giamello JD, Testa E, Ruiz Iturriaga LA, Falcetta A, Serraino C et al. RDW-based clinical score to predict long-term survival in community-acquired pneumonia: a European derivation and validation study. Intern Emerg Med. 2021; 16(6): 1547-1557. DOI:10.1007/s11739-020-02615-6.
Gomez Larrauri A, Gangoiti P, Presa N, Dominguez Herrera A, Donati C, Bruni P et al. Phosphatidic Acid Stimulates Myoblast Proliferation through Interaction with LPA1 and LPA2 Receptors. Int J Mol Sci. 2021; 22(3). DOI:10.3390/ijms22031452.
Gomez Larrauri A, Ouro A, Trueba M, Gomez Munoz A. Regulation of cell growth, survival and migration by ceramide 1-phosphate - implications in lung cancer progression and inflammation. Cell Signal. 2021; 83: 109980-109980. DOI:10.1016/j.cellsig.2021.109980.
Gomez Carballo C, Pedrero S. Carmustine Pulmonary Toxicity: A Diagnosis to Bear in Mind Even in Times of COVID. Arch Bronconeumol. 2021; 57: 52-54. DOI:10.1016/j.arbres.2021.01.009.
Cano Jimenez E, Vazquez Rodriguez T, Martin Robles I, Castillo Villegas D, Juan Garcia J, Bollo de Miguel E et al. Diagnostic delay of associated interstitial lung disease increases mortality in rheumatoid arthritis. Sci Rep. 2021; 11(1): 9184-9184. DOI:10.1038/s41598-021-88734-2.
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Crespo Lessmann A, Bernal S, Del Rio E, Rojas E, Martinez Rivera C, Marina N et al. Association of the CFTR gene with asthma and airway mucus hypersecretion. PLoS One. 2021; 16(6): 251881-251881. DOI:10.1371/journal.pone.0251881.
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Tesis del grupo
Autor/a: Luis Alberto Ruiz Iturriaga. Título: "La bacteriemia como marcador pronóstico de la neumonía neumocócica adquirida en la comunidad en pacientes inmunocompetentes hospitalizados". Directores/as: Dr. Guillermo Quindós Andrés, Dr. Rafael Zalacain Jorge.
