Farmacoterapia y seguridad de los medicamentos
Actividades del grupo
Somos un grupo de profesionales, farmacéuticos de Hospital, Unidad de Farmacovigilancia y Departamento de Farmacologia de la UPV/EHU. El trabajo asistencial que presta la farmacia hospitalaria en la actualidad es una atención individualizada a cada paciente, tanto durante su asistencia hospitalaria como en el ámbito extrahospitalario. Además, entendemos que la excelencia para prestar dicho servicio debe ir ligada a una inquietud investigadora, que la retroalimente.
En lo que a la investigación se refiere, nuestro objetivo fundamental es promover la utilización segura de los medicamentos, a través de diversas líneas de investigación, en las que aspiramos a integrar personas de los diferentes subgrupos y estamos abiertos a grupos o personas de otras organizaciones.
Nuestras líneas básicas son:
- Investigación en el manejo seguro en la utilización de los medicamentos:
- Farmacovigilancia. Vigilancia de la seguridad de los medicamentos postcomercializacion.
- Errores de medicación. Detección, comunicación, estrategias de minimización de su impacto.
- Manejo de medicamentos biopeligrosos.
- Investigación en farmacoterapia, farmacoepidemiología y atención farmacéutica continuada:
- Farmacoepidemiología. Interés preferente en fármacos utilizados en neuropsiquiatría.
- Nuevos canales de atención farmacéutica y visibilidad del farmacéutico como consultor del medicamento.
- Desarrollo, implantación e investigación en los programas de optimización de antibióticos.
- Individualización de los tratamientos y atención farmacéutica centrada en el paciente:
- Utilización de la farmacocinética clínica y farmacogenética para la individualización y optimización de la terapéutica.
- Adecuación individualizada de los tratamientos (polifarmacia, medicación potencialmente inapropiada y conciliación de la medicación).
- Estudios farmacoepidemiológicos que exploten los datos generados por la práctica clínica, con un enfoque eminentemente translacional:
- Modelos de procesamiento del lenguaje natural para detección de efectos adversos en la historia clínica electrónica.
- Utilización de tecnología Business Intelligence, KNIME…
- Estudios de utilización de medicamentos orientados a los resultados en salud.
Coordinador/a del grupo
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Olatz Ibarra Barrueta
Coordinadora de grupo
mariaolatz.ibarrabarrueta@osakidetza.eus
CV resumen
Miembros del grupo
Publicaciones del grupo
Barrueta OI, Martin EG, Sanchez PL, Herraiz ER, Bohorquez VM, Larisgoitia AA. [TRANSLATED ARTICLE] Biological and immunosuppressive medications in pregnancy, breastfeeding and fertility in immune mediated diseases. Farm Hosp. 2023; 47(1): 39-49. DOI:10.1016/j.farma.2022.12.016.
Ibarra Barrueta O, Garcia Martin E, Lopez Sanchez P, Ramirez Herraiz E, Merino Bohorquez V, Ais Larisgoitia A. Biological and immunosuppressive medications in pregnancy, breastfeeding and fertility in immune mediated diseases. Farm Hosp. 2023; 47(1): 39-49. DOI:10.1016/j.farma.2022.12.005.
Subhani S, Lukacova V, Kim C, Rodriguez Vera L, Muniz P, Rodriguez M, et al. Leveraging Physiologically Based Modelling to Provide Insights on the Absorption of Paliperidone Extended-Release Formulation under Fed and Fasting Conditions. Pharmaceutics. 2023; 15(2). DOI:10.3390/pharmaceutics15020629.
Gamboa L, Lafuente AS, Morera Herreras T, Garcia M, Aguirre C, Lertxundi U. Analysis of heat stroke and heat exhaustion cases in EudraVigilance pharmacovigilance database. Eur J Clin Pharmacol. 2023; 79(5): 679-685. DOI:10.1007/s00228-023-03487-3.
Carral N, Lukas JC, Estrade O, Jauregizar N, Morillas H, Suarez E. Non-Adherence in Adult Male Patients with Community-Acquired Pneumonia: Relative Forgiveness of Amoxicillin versus Respiratory Fluoroquinolones. Antibiotics-Basel. 2023; 12(5). DOI:10.3390/antibiotics12050838.
Vecilla DF, Matheus MPR, Gutierrez MJU, Muro FEC, Vivanco CA, Azkarreta IL, et al. Disseminated Nocardia farcinica infection associated with bacteraemia and osteomyelitis pubis in an elderly patient. Infect Dis. 2023; 55(10): 738-743. DOI:10.1080/23744235.2023.2229425.
Vicente Escrig E, Taberner Bonastre P, Ibarra Barrueta O, Murillo Izquierdo M, Fernandez Llamazares CM, Morillo Verdugo R. Analysis 2016-2021 of the development of the MAPEX outpatient pharmaceutical care Project by regions in Spain. Farm Hosp. 2023. DOI:10.1016/j.farma.2023.08.007.
Mallah N, Zapata Cachafeiro M, Aguirre C, Ibarra Garcia E, Palacios Zabalza I, Macias Garcia F, et al. Synergism interaction between genetic polymorphisms in drug metabolizing enzymes and NSAIDs on upper gastrointestinal haemorrhage: a multicenter case-control study. Ann Med. 2022; 54(1): 379-392. DOI:10.1080/07853890.2021.2016940.
Prieto Montero R, Prieto Castaneda A, Katsumiti A, Sola Llano R, Agarrabeitia AR, Cajaraville MP, et al. Red haloBODIPYs as theragnostic agents: The role of the substitution at meso position. Dyes Pigment. 2022; 198. DOI:10.1016/j.dyepig.2021.110015.
Bilbao Meseguer I, Barrasa H, Rodriguez Gascon A, Asin Prieto E, Maynar J, Sanchez Izquierdo JA, et al. Optimization of levetiracetam dosing regimen in critically ill patients with augmented renal clearance: a Monte Carlo simulation study. J Intensive Care. 2022; 10(1). DOI:10.1186/s40560-022-00611-w.
Subhani S, Kim C, Muniz P, Rodriguez M, van Os S, Suarez E, et al. Application of Physiologically Based Absorption and Pharmacokinetic Modeling in the development process of oral modified release generic products. Eur J Pharm Biopharm. 2022; 176: 87-94. DOI:10.1016/j.ejpb.2022.05.007.
Suarez E, Lemos M, Ruiz Gonzalez EP, Romero AM, Roman Calderon JP, Krikorian A. BURNOUT IN MEDICAL COMMUNITY: ITS RELATIONSHIP WITH COMPASSION AND EMPATHY. Ann Behav Med. 2022; 56(SUPP 1): 129-129
Estrade O, Vozmediano V, Carral N, Isla A, Gonzalez M, Poole R, et al. Key Factors in Effective Patient-Tailored Dosing of Fluoroquinolones in Urological Infections: Interindividual Pharmacokinetic and Pharmacodynamic Variability. Antibiotics (Basel). 2022; 11(5). DOI:10.3390/antibiotics11050641.
Garcia M, Albizua Madariaga I, Lertxundi U, Aguirre C. Subacute thyroiditis and COVID-19 vaccines: a case/non-case study. Endocrine. 2022; 77(3): 480-485. DOI:10.1007/s12020-022-03101-z.
Aguirre C, Palacios Zabalza I, Ceruelo I, Txintxurreta Albizua A, Garcia M. Hypersensitivity reactions associated with iron isomaltoside and ferric carboxymaltose. Eur J Intern Med. 2022. DOI:10.1016/j.ejim.2022.11.030.
Sanmartin Fenollera P, Mangues Bafalluy I, Talens Bolos A, Ibarra Barrueta O, Villamanan Bueno E, Monte Boquet E, et al. Telepharmacy scorecard: Activity and quality indicators for the pharmaceutical care in a hospital pharmacy service. Farm Hosp. 2022; 46(7): 92-105
Duroudier N, Katsumiti A, Mikolaczyk M, Schafer J, Bilbao E, Cajaraville MP. Cell and tissue level responses in mussels Mytilus galloprovincialis dietarily exposed to PVP/PEI coated Ag nanoparticles at two seasons. Sci Total Environ. 2021; 750: 141303-141303. DOI:10.1016/j.scitotenv.2020.141303.
Fernandez Pena A, Katsumiti A, De Basagoiti A, Castano M, Ros G, Sautua S et al. Drug compatibility in neonatal intensive care units: gaps in knowledge and discordances. Eur J Pediatr. 2021; 180(7): 2305-2313. DOI:10.1007/s00431-021-04028-9.
Zazu L, Morera Herreras T, Garcia M, Aguirre C, Lertxundi U. Do cariprazine and brexpiprazole cause impulse control symptoms? A case/non-case study. Eur Neuropsychopharmacol. 2021; 50: 107-111. DOI:10.1016/j.euroneuro.2021.05.001.
Kim C, Lo Re V, Rodriguez M, Lukas JC, Leal N, Campo C et al. Application of a dual mechanistic approach to support bilastine dose selection for older adults. CPT-PHARMACOMET SYST PHARMACOL. 2021; 10(9): 1006-1017. DOI:10.1002/psp4.12671.
Lopera A, Suarez E, Echeverri LM, Maldonado CC, Gaviria C, Duarte MA et al. How to reduce the stigma associated with mental disorders? An intervention based on social norms. Int J Behav Med. 2021; 28(SUPPL 1): 16-16
Montoya S, Suarez E, Hernandez I, Torres S, Lemos M. The role of information in adherence to treatment for people living with HIV: Results of a qualitative study in a Colombian City. Int J Behav Med. 2021; 28(SUPPL 1): 87-87
Garcia M, Lertxundi U, Aguirre C. Tramadol-induced hiccups: a case-noncase study in the European pharmacovigilance database. Ther Adv Drug Saf. 2021; 12. DOI:10.1177/20420986211021230.
Prieto Montero R, Prieto Castaneda A, Katsumiti A, Cajaraville MP, Agarrabeitia AR, Ortiz MJ et al. Functionalization of Photosensitized Silica Nanoparticles for Advanced Photodynamic Therapy of Cancer. Int J Mol Sci. 2021; 22(12). DOI:10.3390/ijms22126618.
Garcia Salvador A, Katsumiti A, Rojas E, Aristimuno C, Betanzos M, Martinez Moro M et al. A Complete In Vitro Toxicological Assessment of the Biological Effects of Cerium Oxide Nanoparticles: From Acute Toxicity to Multi-Dose Subchronic Cytotoxicity Study. Nanomaterials. 2021; 11(6). DOI:10.3390/nano11061577.
Mallah N, Zapata Cachafeiro M, Aguirre C, Ibarra Garcia E, Palacios Zabalza I, Macias Garcia F et al. A multicenter case-control study of the effect of e-nos VNTR polymorphism on upper gastrointestinal hemorrhage in NSAID users. Sci Rep. 2021; 11(1): 19923-19923. DOI:10.1038/s41598-021-99402-w.
De Basagoiti A, Fernandez A, Mendiola S, De Miguel M, Guerra E, Loureiro B et al. Intravenous drug use in neonatal intensive care units. Eur J Hosp Pharm. 2021; 28(6): 341-345. DOI:10.1136/ejhpharm-2019-001939.
Bilbao Meseguer I, Barrasa H, Asin Prieto E, Alarcia Lacalle A, Rodriguez Gascon A, Maynar J et al. Population Pharmacokinetics of Levetiracetam and Dosing Evaluation in Critically Ill Patients with Normal or Augmented Renal Function. Pharmaceutics. 2021; 13(10). DOI:10.3390/pharmaceutics13101690.
Serrano I, Garcia M, Mintegi S, Azkunaga B, Grupo de Trabajo de Intoxicaciones de la Sociedad Espanola de Urgencias de P. Appropriateness of antidotes administered in Spanish pediatric emergency departments. Emergencias. 2021; 33(6)
Katsumiti A, Losada Carrillo MP, Barros M, Cajaraville MP. Polystyrene nanoplastics and microplastics can act as Trojan horse carriers of benzo(a)pyrene to mussel hemocytes in vitro. Sci Rep. 2021; 11(1). DOI:10.1038/s41598-021-01938-4.
Santobena JS, Gonzalez I, Gonzalez B, Rezola A, Echevarria E, Castro S et al. Differences in host inflammatory response and severity according to gender in COVID-19. Eur Resp J. 2021; 58. DOI:10.1183/13993003.congress-2021.PA3253.
Baré M, Herranz S, Jordana R, Gorgas MQ, Ortonobes S, Sevilla D, et al. Multimorbidity patterns in chronic older patients, potentially inappropriate prescribing and adverse drug reactions: protocol of the multicentre prospective cohort study MoPIM. Bmj Open. 2020; 10(1). DOI:10.1136/bmjopen-2019-033322.
Lertxundi U, Hernández R, Medrano J, Orive G. Drug pollution and pharmacotherapy in psychiatry: A "platypus" in the room. Eur Psychiat. 2020; 63(1). DOI:10.1192/j.eurpsy.2020.32.
Mallah N, Zapata Cachafeiro M, Aguirre C, Ibarra Garcia E, Palacios Zabalza I, Macias Garcia F, et al. Polymorphisms Involved in Platelet Activation and Inflammatory Response on Aspirin-Related Upper Gastrointestinal Bleeding: A Case-Control Study. Front Pharmacol. 2020; 11. DOI:10.3389/fphar.2020.00860.
Garcia M, Arteche Martinez U, Lertxundi U, Aguirre C. SGLT2 Inhibitors and Bladder Cancer: Analysis of Cases Reported in the European Pharmacovigilance Database. J Clin Pharmacol. 2021; 61(2): 187-192. DOI:10.1002/jcph.1722.
Mallah N, Zapata Cachafeiro M, Aguirre C, Ibarra Garcia E, Palacios Zabalza I, Macias Garcia F, et al. Influence of Polymorphisms Involved in Platelet Activation and Inflammatory Response on Aspirin-Related Upper Gastrointestinal Bleeding: A Case-Control Study (vol 11, 860, 2020). Front Pharmacol. 2020; 11. DOI:10.3389/fphar.2020.01072.
De Basagoiti A, Anton X, Calleja A, De Miguel M, Guerra E, Loureiro B, et al. Analysis of standard concentrations of continuous infusions in nine Spanish neonatal intensive care units. Eur J Hosp Pharm. 2020; 29(1): 50-54. DOI:10.1136/ejhpharm-2019-002194.
Alegria Lertxundi I, Aguirre C, Bujanda L, Fernandez FJ, Polo F, Ordovas JM, et al. Gene-Diet Interactions in Colorectal Cancer: Survey Design, Instruments, Participants and Descriptive Data of a Case-Control Study in the Basque Country. Nutrients. 2020; 12(8): 1-20. DOI:10.3390/nu12082362.
De Basagoiti A, Katsumiti A, Abascal S, Bustinza A, Lopez Gimenez LR, Pascual P, et al. Physical compatibility of alprostadil with selected drugs commonly used in the neonatal intensive care units. Eur J Pediatr. 2020; 180(4): 1169-1176. DOI:10.1007/s00431-020-03854-7.
Prieto Montero R, Katsumiti A, Cajaraville MP, Lopez Arbeloa I, Martinez V. Functionalized Fluorescent Silica Nanoparticles for Bioimaging of Cancer Cells. Sensors (Basel). 2020; 20(19). DOI:10.3390/s20195590.
Katsumiti A, Ruenraroengsak P, Cajaraville MP, Thorley AJ, Tetley TD. Immortalisation of primary human alveolar epithelial lung cells using a non-viral vector to study respiratory bioreactivity in vitro. Sci Rep. 2020; 10(1): 20486-20486. DOI:10.1038/s41598-020-77191-y.
Lertxundi Etxebarria U, Palacios Zabalza I, Ibarrondo I, Domingo Echaburu S, Hernandez R, Isla A, et al. Pharmacotherapeutic management of Parkinson's disease inpatients: how about asking hospital pharmacists?. Eur J Hosp Pharm. 2020; 28(E1): 140-145. DOI:10.1136/ejhpharm-2020-002461.
Ibarra Barrueta O, Ibarra Garcia E, Perez Diez E. Implementation of a pharmacy e-interconsultation integrated in patient medical record. Eur J Hosp Pharm. 2020; 28(E1): 124-127. DOI:10.1136/ejhpharm-2020-002224.
García MG, Larrinaga Torrontegui U, Eduardo Martinez E, Lertxundi U, Palacios Zabalza I, Aguirre C. Fractures Related to Tenofovir: A Case/Noncase Study in the European Pharmacovigilance Database. AM J THER. 2019; 26(5): 589-592. DOI:10.1097/MJT.0000000000000718.
Lertxundi U, Erezuma I, Hernandez R, Medrano J, Garcia M, Aguirre C. Antipsychotics and pituitary tumors: An analysis of the European pharmacovigilance database (EudraVigilance). Int Clin Psychopharmacol. 2019; 34(2): 89-92. DOI:10.1097/YIC.0000000000000247.
Ibarra Barrueta O, Mora Atorrasagasti O, Aguirre U, Jose Legarreta M, Illaro Uranga A, Morillo Verdugo R. Pilot study to develop and validate a questionnaire based on HIV symptoms index. Farm Hosp. 2019; 43(3): 87-93. DOI:10.7399/fh.11127.
Manita P, Lertxundi U, Palacios I, Cardenas M, Garcia M, Aguirre C. Severe hypersensitivity reactions associated with iron (iii) isomaltoside and ferric carboxymaltose. Analysis of eudravigilance database. Eur J Clin Pharmacol. 2019; 75(1): 102-103
Aguirre C, Garcia M. Reply: On the safety of intravenous iron formulations. Med Clin. 2019; 152(5): 204-205. DOI:10.1016/j.medcli.2018.05.033.
Domingo C, Regidor I, Alonso E, Besga A, Orozco D, Nuno R, et al. Healthcare staff perceptions of integrated care in a programme for complex chronic patients admitted to hospital because of heart failure (ProMIC). Int J Care Coord. 2019; 22(2): 81-89. DOI:10.1177/2053434519840458.
Alegria Lertxundi I, Aguirre C, Bujanda L, Fernández FJ, Polo F, Ordovás JM, et al. Single nucleotide polymorphisms associated with susceptibility for development of colorectal cancer: Case-control study in a Basque population. PLoS One. 2019; 14(12): 225779-225779. DOI:10.1371/journal.pone.0225779.
Domingo Echaburu S, Lertxundi Etxebarria U, Hernandez Palacios R, Medrano Albeniz J. Comments on the Anticholinergic Burden Calculator Web Tool. Farm Hosp. 2019; 43(5): 168-169. DOI:10.7399/fh.11298.
Palacios Zabalza I, Camino Rodríguez E, Aguirre C. Kounis syndrome induced by ranitidine. Med Clin. 2018; 151(9): 51-53. DOI:10.1016/j.medcli.2018.02.006.
Ruiz B, Aguirre U, Estany Gestal A, Rodella L, Ruiz P, Figueiras A, et al. Only full adherence to proton pump inhibitors protects against drug-induced upper gastrointestinal bleeding. Eur J Clin Pharmacol. 2018; 74(11): 1503-1511. DOI:10.1007/s00228-018-2523-4.
Garcia MG, Etxebarria UL, Martinez UA, Gomez CA. SGLT2 inhibitors and bladder cancer: analysis of cases reported in the European pharmacovigilance database (EUDRAVIGILANCE). Basic Clin Pharmacol Toxicol. 2018; 123: 40-40
Lertxundi U, Hernandez R, Corcostegui B. Influence of an inconsistent appearance of antipsychotics on drug adherence in patients with schizophrenia (vol 97, e12990, 2018). Medicine (Baltimore). 2018; 97(47). DOI:10.1097/MD.0000000000013496.
Tesis del grupo
Autor/a: Ainara Campino Villegas. Título: Análisis de la incidencia y características de los errores de medicación en una UCIN de un hospital terciario. Director/a: Dr. Luis Carlos Abecia Inchaurregui, Dr. Iñaki Gutiérrez Ibarlucea.
