Responsive Image

Responsive Image

Glicoinmunología estructural

Líneas de investigación

Protein glycosylation is one of the most important post-translational modifications that regulate a large number of physiological functions, including immunity. Antibodies are proteins of the adaptive immune system essential for the identification and neutralization of bacteria, viruses or tumor cells. All antibodies subclasses exhibit a characteristic and complex degree of glycosylation. This glycosylation modulates not only the structure of antibodies but also contributes to their effector and immunogenic functions. However, in numerous diseases, the glycosylation of antibodies can be altered, as is the case in certain autoimmune disorders, infectious diseases, aging and different types of cancer. Our main lines of research are:

  • Determination of the role of glycosylation in physiological and pathological processes.
  • Study of the role of glycosylation in autoimmune diseases.
  • Determination of molecular mechanisms mediated by glycosylation in autoimmune diseases for the design of new diagnostic and therapeutic tools.
Foto grupo

Integrantes del grupo

Publicaciones del grupo

Sastre DE, Sultana N, V A S Navarro M, Huliciak M, Du J, Cifuente JO, et al. Human gut microbes express functionally distinct endoglycosidases to metabolize the same N-glycan substrate. Nat Commun. 2024; 15(1): 5123-5123. DOI:10.1038/s41467-024-48802-3.

Perez Cruz C, Moraleda Montoya A, Liebana R, Terrones O, Arrizabalaga U, Garcia Alija M, et al. Mechanisms of recalcitrant fucoidan breakdown in marine Planctomycetota. Nat Commun. 2024; 15(1): 10906-10906. DOI:10.1038/s41467-024-55268-w.

Trastoy B, Du JJ, Cifuente JO, Rudolph L, Garcia Alija M, Klontz EH, et al. Mechanism of antibody-specific deglycosylation and immune evasion by Streptococcal IgG-specific endoglycosidases. Nat Commun. 2023; 14(1): 1705-1705. DOI:10.1038/s41467-023-37215-3.

Anso I, Naegeli A, Cifuente JO, Orrantia A, Andersson E, Zenarruzabeitia O, et al. Turning universal O into rare Bombay type blood. Nat Commun. 2023; 14(1): 1765-1765. DOI:10.1038/s41467-023-37324-z.

García Alija M, van Moer B, Sastre DE, Azzam T, Du JJ, Trastoy B, et al. Modulating antibody effector functions by Fc glycoengineering. Biotechnol Adv. 2023; 67. DOI:10.1016/j.biotechadv.2023.108201.

Du JJ, Sastre D, Trastoy B, Roberts B, Deredge D, Klontz EH, et al. Mass Spectrometry-Based Methods to Determine the Substrate Specificities and Kinetics of N-Linked Glycan Hydrolysis by Endo-beta-N-Acetylglucosaminidases. Methods Mol Biol. 2023; 2674: 147-167. DOI:10.1007/978-1-0716-3243-7_10.

Cioetto Mazzabò L, Boldrin F, Beauvineau C, Speth M, Marina A, Namouchi A, et al. SigH stress response mediates killing of Mycobacterium tuberculosis by activating nitronaphthofuran prodrugs via induction of Mrx2 expression. Nucleic Acids Res. 2023; 51(1): 144-165. DOI:10.1093/nar/gkac1173.

Garcia M,Du JJ,Ordonez I,Diz A,Moraleda A,Sultana N et al. Mechanism of cooperative N-glycan processing by the multi-modular endoglycosidase EndoE. Nat Commun. 2022. 13. (1):1137. IF:14,919. (1).

Trastoy B,Du JJ,Garcia M,Li C,Klontz EH,Wang LX et al. Sculpting therapeutic monoclonal antibody N-glycans using endoglycosidases. Curr. Opin. Struct. Biol. 2022. 72. p. 248-259. IF:6,809. (1).

Tesis del grupo

Autor/a: Itxaso Anso Miqueleiz. Título: Structural basis of bacterial glyeans biosynthesis and processing: ímpact in human health and disease. Directores/as: Marcelo Guerin y Xabier Contreras Gómez. URL: http://hdl.handle.net/10810/62643.

Responsive Image

Plaza Cruces S/N | 48903 Barakaldo
Tel.: 94 618 26 22

© 2025 IIS Biobizkaia